Proteomic Investigation of the Sinulariolide-Treated Melanoma Cells A375: Effects on the Cell Apoptosis through Mitochondrial-Related Pathway and Activation of Caspase Cascade

Proteomic Investigation of the Sinulariolide-Treated Melanoma Cells A375: Effects on the Cell Apoptosis through Mitochondrial-Related Pathway and Activation of Caspase Cascade

Sinulariolide is an active compound isolated from the cultured soft coral Sinularia flexibilis. In this study, we investigated the effects of sinulariolide on A375 melanoma cell growth and protein expression. Sinulariolide suppressed the proliferation and migration of melanoma cells in a concentrati...

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Bibliographic Details
Main Authors: Yu-Jen Wu, Yu-Hsuan Lo, Yu-Kuei Chen, Wen-Ing Hwang, Jen-Jie Lin, Zih-Yan Yang, Jui-Hsin Su, Chien-Chih Chiu, Hsing-Hui Li
Format: Article
Language:English
Published: MDPI AG 2013-07-01
Series:Marine Drugs
Subjects:
melanoma
sinulariolide
proteomic
mitochondria
apoptosis
caspase cascade
Online Access:http://www.mdpi.com/1660-3397/11/7/2625

Internet

http://www.mdpi.com/1660-3397/11/7/2625

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