PPP1R35 is a novel centrosomal protein that regulates centriole length in concert with the microcephaly protein RTTN

PPP1R35 is a novel centrosomal protein that regulates centriole length in concert with the microcephaly protein RTTN

Centrosome structure, function, and number are finely regulated at the cellular level to ensure normal mammalian development. Here, we characterize PPP1R35 as a novel bona fide centrosomal protein and demonstrate that it is critical for centriole elongation. Using quantitative super-resolution micro...

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Bibliographic Details
Main Authors: Andrew Michael Sydor, Etienne Coyaud, Cristina Rovelli, Estelle Laurent, Helen Liu, Brian Raught, Vito Mennella
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-08-01
Series:eLife
Subjects:
centrosome
centriole
centriole elongation
centriole duplication
structured illumination microscopy
primary recessive microcephaly
Online Access:https://elifesciences.org/articles/37846

Internet

https://elifesciences.org/articles/37846

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