Host Protein BAG3 is a Negative Regulator of Lassa VLP Egress

Host Protein BAG3 is a Negative Regulator of Lassa VLP Egress

Lassa fever virus (LFV) belongs to the Arenaviridae family and can cause acute hemorrhagic fever in humans. The LFV Z protein plays a central role in virion assembly and egress, such that independent expression of LFV Z leads to the production of virus-like particles (VLPs) that mimic egress of infe...

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Bibliographic Details
Main Authors: Ziying Han, Michael P. Schwoerer, Philip Hicks, Jingjing Liang, Gordon Ruthel, Corbett T. Berry, Bruce D. Freedman, Cari A. Sagum, Mark T. Bedford, Sachdev S. Sidhu, Marius Sudol, Ronald N. Harty
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Diseases
Subjects:
Lassa fever virus
VLPs
budding
BAG3
L-domain
virus-host interaction
Ebola
WW-domain
autophagy
Online Access:http://www.mdpi.com/2079-9721/6/3/64

Internet

http://www.mdpi.com/2079-9721/6/3/64

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