UBR-5, a Conserved HECT-Type E3 Ubiquitin Ligase, Negatively Regulates Notch-Type Signaling in Caenorhabditis elegans

UBR-5, a Conserved HECT-Type E3 Ubiquitin Ligase, Negatively Regulates Notch-Type Signaling in Caenorhabditis elegans

Notch-type signaling mediates cell−cell interactions important for animal development. In humans, reduced or inappropriate Notch signaling activity is associated with various developmental defects and disease states, including cancers. Caenorhabditis elegans expresses two Notch-type receptors, GLP-1...

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Bibliographic Details
Main Authors: Komal Safdar, Anniya Gu, Xia Xu, Vinci Au, Jon Taylor, Stephane Flibotte, Donald G. Moerman, Eleanor M. Maine
Format: Article
Language:English
Published: Oxford University Press 2016-07-01
Series:G3: Genes, Genomes, Genetics
Subjects:
Notch
germ cell
GLP-1
LIN-12
HECT domain
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.116.027805

Internet

http://g3journal.org/lookup/doi/10.1534/g3.116.027805

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