Hyperphosphorylation of Tau Associates With Changes in Its Function Beyond Microtubule Stability

Hyperphosphorylation of Tau Associates With Changes in Its Function Beyond Microtubule Stability

Tau is a neuronal microtubule associated protein whose main biological functions are to promote microtubule self-assembly by tubulin and to stabilize those already formed. Tau also plays an important role as an axonal microtubule protein. Tau is an amazing protein that plays a key role in cognitive...

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Bibliographic Details
Main Authors: Alejandra D. Alonso, Leah S. Cohen, Christopher Corbo, Viktoriya Morozova, Abdeslem ElIdrissi, Greg Phillips, Frida E. Kleiman
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
tau
PH-tau
hyperphosphorylation
propagation
microtubules
neurodegeneration
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00338/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00338/full

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