Chromatin accessibility landscape of pediatric T‐lymphoblastic leukemia and human T‐cell precursors

Chromatin accessibility landscape of pediatric T‐lymphoblastic leukemia and human T‐cell precursors

Abstract We aimed at identifying the developmental stage at which leukemic cells of pediatric T‐ALLs are arrested and at defining leukemogenic mechanisms based on ATAC‐Seq. Chromatin accessibility maps of seven developmental stages of human healthy T cells revealed progressive chromatin condensation...

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Bibliographic Details
Main Authors: Büşra Erarslan‐Uysal, Joachim B Kunz, Tobias Rausch, Paulina Richter‐Pechańska, Ianthe AEM vanBelzen, Viktoras Frismantas, Beat Bornhauser, Diana Ordoñez‐Rueada, Malte Paulsen, Vladimir Benes, Martin Stanulla, Martin Schrappe, Gunnar Cario, Gabriele Escherich, Kseniya Bakharevich, Renate Kirschner‐Schwabe, Cornelia Eckert, Tsvetomir Loukanov, Matthias Gorenflo, Sebastian M Waszak, Jean‐Pierre Bourquin, Martina U Muckenthaler, Jan O Korbel, Andreas E Kulozik
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:EMBO Molecular Medicine
Subjects:
ATAC‐Seq
chromatin accessibility
T‐cell development
T‐cell leukemia
Online Access:https://doi.org/10.15252/emmm.202012104

Internet

https://doi.org/10.15252/emmm.202012104

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