Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

RasGRP1 and SOS are Ras-specific nucleotide exchange factors that have distinct roles in lymphocyte development. RasGRP1 is important in some cancers and autoimmune diseases but, in contrast to SOS, its regulatory mechanisms are poorly understood. Activating signals lead to the membrane recruitment...

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Bibliographic Details
Main Authors: Jeffrey S Iwig, Yvonne Vercoulen, Rahul Das, Tiago Barros, Andre Limnander, Yan Che, Jeffrey G Pelton, David E Wemmer, Jeroen P Roose, John Kuriyan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-07-01
Series:eLife
Subjects:
cell signaling
nucleotide exchange factor
diacylglycerol
Online Access:https://elifesciences.org/articles/00813

Internet

https://elifesciences.org/articles/00813

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