The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

The mechanistic Target of Rapamycin complex 1 (mTORC1) senses intracellular amino acid levels through an intricate machinery, which includes the Rag GTPases, Ragulator and vacuolar ATPase (V-ATPase). The membrane-associated E3 ubiquitin ligase ZNRF2 is released into the cytosol upon its phosphorylat...

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Bibliographic Details
Main Authors: Gerta Hoxhaj, Edward Caddye, Ayaz Najafov, Vanessa P Houde, Catherine Johnson, Kumara Dissanayake, Rachel Toth, David G Campbell, Alan R Prescott, Carol MacKintosh
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-04-01
Series:eLife
Subjects:
ZNRF2
mTORC1
amino acid sensing
V-ATPase
PP6
Ragulator
Online Access:https://elifesciences.org/articles/12278

Internet

https://elifesciences.org/articles/12278

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