Vitamin C Administration by Intravenous Infusion Increases Tumor Ascorbate Content in Patients With Colon Cancer: A Clinical Intervention Study

Vitamin C Administration by Intravenous Infusion Increases Tumor Ascorbate Content in Patients With Colon Cancer: A Clinical Intervention Study

The use of high dose ascorbate infusions in cancer patients is widespread, but without evidence of efficacy. Several mechanisms whereby ascorbate could affect tumor progression have been proposed, including: (i) the localized generation of cytotoxic quantities of H2O2; (ii) ascorbate-dependent activ...

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Bibliographic Details
Main Authors: Gabi U. Dachs, Jamish Gandhi, Christina Wohlrab, Anitra C. Carr, Helen R. Morrin, Juliet M. Pullar, Simone B. Bayer, Tim W. Eglinton, Bridget A. Robinson, Margreet C. M. Vissers
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Oncology
Subjects:
vitamin C
plasma
tumor
colorectal cancer
normal mucosa
tumor hypoxia
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.600715/full

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https://www.frontiersin.org/articles/10.3389/fonc.2020.600715/full

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