Estrogen rescues heart failure through estrogen receptor Beta activation

Estrogen rescues heart failure through estrogen receptor Beta activation

Abstract Background Recently, we showed that exogenous treatment with estrogen (E2) rescues pre-existing advanced heart failure (HF) in mice. Since most of the biological actions of E2 are mediated through the classical estrogen receptors alpha (ERα) and/or beta (ERβ), and both these receptors are p...

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Bibliographic Details
Main Authors: Andrea Iorga, Soban Umar, Gregoire Ruffenach, Laila Aryan, Jingyuan Li, Salil Sharma, Negar Motayagheni, Rangarajan D. Nadadur, Jean C. Bopassa, Mansoureh Eghbali
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Biology of Sex Differences
Subjects:
Estrogen
Heart failure
Angiogenesis
Fibrosis
Estrogen receptor Beta
Estrogen receptor alpha
Online Access:http://link.springer.com/article/10.1186/s13293-018-0206-6

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http://link.springer.com/article/10.1186/s13293-018-0206-6

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