A low-molecular-weight compound exerts anticancer activity against breast and lung cancers by disrupting EGFR/Eps8 complex formation

A low-molecular-weight compound exerts anticancer activity against breast and lung cancers by disrupting EGFR/Eps8 complex formation

Abstract Background Epidermal growth factor receptor (EGFR) and epidermal growth factor receptor pathway substrate 8 (Eps8) have been widely reported to be expressed in various tumors. Eps8 is an important active kinase substrate of EGFR that directly binds to the juxtamembrane (JXM) domain of EGFR...

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Bibliographic Details
Main Authors: Meifang Li, Jilong Yang, Lenghe Zhang, Sanfang Tu, Xuan Zhou, Ze Tan, Weijun Zhou, Yanjie He, Yuhua Li
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Epidermal growth factor receptor (EGFR)
Epidermal growth factor receptor pathway substrate 8 (Eps8)
Breast cancer
NSCLC, small-molecule inhibitor
Online Access:http://link.springer.com/article/10.1186/s13046-019-1207-y

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http://link.springer.com/article/10.1186/s13046-019-1207-y

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