Lapatinib sensitivity in nasopharyngeal carcinoma is modulated by SIRT2-mediated FOXO3 deacetylation

Lapatinib sensitivity in nasopharyngeal carcinoma is modulated by SIRT2-mediated FOXO3 deacetylation

Abstract Background Chemoresistance is an obstacle to the successful treatment of nasopharyngeal carcinoma (NPC). Lapatinib is a targeted tyrosine kinase inhibitor therapeutic drug also used to treat NPC, but high doses are often required to achieve a result. To investigate the mechanism for the dev...

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Bibliographic Details
Main Authors: Sathid Aimjongjun, Zimam Mahmud, Yannasittha Jiramongkol, Glowi Alasiri, Shang Yao, Ernesto Yagüe, Tavan Janvilisri, Eric W.-F. Lam
Format: Article
Language:English
Published: BMC 2019-11-01
Series:BMC Cancer
Subjects:
Nasopharyngeal carcinoma
Sirtuin
FOXO3
Chemoresistance
Lapatinib
Acetylation
Online Access:http://link.springer.com/article/10.1186/s12885-019-6308-7

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http://link.springer.com/article/10.1186/s12885-019-6308-7

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