Hedgehog/GLI1 Transcriptionally Regulates FANCD2 in Ovarian Tumor Cells: Its Inhibition Induces HR-Deficiency and Synergistic Lethality with PARP Inhibition.

Hedgehog/GLI1 Transcriptionally Regulates FANCD2 in Ovarian Tumor Cells: Its Inhibition Induces HR-Deficiency and Synergistic Lethality with PARP Inhibition.

Ovarian cancer (OC) is one of the most lethal type of cancer in women due to a lack of effective targeted therapies and high rates of treatment resistance and disease recurrence. Recently Poly (ADP-ribose) polymerase inhibitors (PARPi) have shown promise as chemotherapeutic agents; however, their ef...

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Bibliographic Details
Main Authors: Chinnadurai Mani, Kaushlendra Tripathi, Sandeep Chaudhary, Ranganatha R. Somasagara, Rodney P. Rocconi, Chiquito Crasto, Mark Reedy, Mohammad Athar, Komaraiah Palle
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
GLI1
Ovarian Cancer
FANCD2
GANT61
Olaparib
and Homologous recombination deficiency
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558621000518

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http://www.sciencedirect.com/science/article/pii/S1476558621000518

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