Characterization of a Single Chain Fv Antibody that Reacts with Free Morphine

An immune phage library derived from mice, hyperimmunized with morphine-conjugated BSA, was used to isolate a single-chain Fv (scFv) clone, M86, with binding activity to morphine-conjugated thyroglobulin (morphine-C-Tg) but not to codeine-, cocaine-, or ketamine-conjugated Tg. Surface plasmon resona...

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Bibliographic Details
Main Authors: Kazuhisa Sugimura, Yuta Hamazoe, Koji Arizono, Shinya Kohra, Koichi Tanaka, Mariko Kamegawa, Miho Matsukizono
Format: Article
Language:English
Published: MDPI AG 2013-02-01
Series:Antibodies
Subjects:
Online Access:http://www.mdpi.com/2073-4468/2/1/93