Caspase-11-Gasdermin D-Mediated Pyroptosis Is Involved in the Pathogenesis of Atherosclerosis

Caspase-11-Gasdermin D-Mediated Pyroptosis Is Involved in the Pathogenesis of Atherosclerosis

Background: Pyroptosis is a form of cell death triggered by proinflammatory signals. Recent studies have reported that oxidized phospholipids function as caspase-11 agonists to induce noncanonical inflammasome activation in immune cells. As the levels of oxidized phospholipids derived from ox-LDL ar...

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Bibliographic Details
Main Authors: Mengqing Jiang, Xuejing Sun, Suzhen Liu, Yan Tang, Yunming Shi, Yuanyuan Bai, Yujie Wang, Qiong Yang, Qize Yang, Weihong Jiang, Hong Yuan, Qixia Jiang, Jingjing Cai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
atherosclerosis
inflammation
pyroptosis
macrophage
caspase-11
gasdermin D
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.657486/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.657486/full

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