Reduced Effect of Anticonvulsants on AMPA Receptor Palmitoylation-Deficient Mice

Reduced Effect of Anticonvulsants on AMPA Receptor Palmitoylation-Deficient Mice

AMPA receptors are responsible for fast excitatory synaptic transmission in the mammalian brain. Post-translational protein S-palmitoylation of AMPA receptor subunits GluA1-4 reversibly regulates synaptic AMPA receptor expression, resulting in long-lasting changes in excitatory synaptic strengths. O...

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Bibliographic Details
Main Authors: Madoka Iizumi, Akiko Oota-Ishigaki, Mariko Yamashita, Takashi Hayashi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
phenytoin
trimethadione
anticonvulsant
palmitoylation
AMPA receptor
synapse
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.711737/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.711737/full

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