A computational strategy for finding novel targets and therapeutic compounds for opioid dependence.

Opioids are widely used for treating different types of pains, but overuse and abuse of prescription opioids have led to opioid epidemic in the United States. Besides analgesic effects, chronic use of opioid can also cause tolerance, dependence, and even addiction. Effective treatment of opioid addi...

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Bibliographic Details
Main Authors: Xiaojun Wu, Siwei Xie, Lirong Wang, Peihao Fan, Songwei Ge, Xiang-Qun Xie, Wei Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6221321?pdf=render