Heme as Possible Contributing Factor in the Evolvement of Shiga-Toxin Escherichia coli Induced Hemolytic-Uremic Syndrome

Heme as Possible Contributing Factor in the Evolvement of Shiga-Toxin Escherichia coli Induced Hemolytic-Uremic Syndrome

Shiga-toxin (Stx)-producing Escherichia coli hemolytic-uremic syndrome (STEC-HUS) is one of the most common causes of acute kidney injury in children. Stx-mediated endothelial injury initiates the cascade leading to thrombotic microangiopathy (TMA), still the exact pathogenesis remains elusive. Inte...

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Bibliographic Details
Main Authors: Kioa L. Wijnsma, Susan T. Veissi, Sem de Wijs, Thea van der Velden, Elena B. Volokhina, Frank A. D. T. G. Wagener, Nicole. C. A. J. van de Kar, L. P. van den Heuvel
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
heme
hemopexin
STEC-HUS
TMA
HO-1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.547406/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.547406/full

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