GADD45B Promotes Glucose-Induced Renal Tubular Epithelial-Mesenchymal Transition and Apoptosis via the p38 MAPK and JNK Signaling Pathways

GADD45B Promotes Glucose-Induced Renal Tubular Epithelial-Mesenchymal Transition and Apoptosis via the p38 MAPK and JNK Signaling Pathways

Growth arrest and DNA damage-inducible beta (GADD45B) is closely linked with cell cycle arrest, DNA repair, cell survival, or apoptosis in response to stress and is known to regulate the mitogen-activated protein kinase (MAPK) pathway. Here, using an RNA sequencing approach, we determined that GADD4...

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Bibliographic Details
Main Authors: Mei Xue, Hongxi Sun, Rong Xu, Yue Wang, Jun Guo, Xiaoyu Li, Ying Cheng, Chaofei Xu, Chao Tang, Bei Sun, Liming Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Physiology
Subjects:
GADD45B
p38 MAPK
JNK
diabetes
renal tubular injury
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.01074/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.01074/full

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