Prediction of Human Phenotype Ontology terms by means of hierarchical ensemble methods

Prediction of Human Phenotype Ontology terms by means of hierarchical ensemble methods

Abstract Background The prediction of human gene–abnormal phenotype associations is a fundamental step toward the discovery of novel genes associated with human disorders, especially when no genes are known to be associated with a specific disease. In this context the Human Phenotype Ontology (HPO)...

Full description

Bibliographic Details
Main Authors: Marco Notaro, Max Schubach, Peter N. Robinson, Giorgio Valentini
Format: Article
Language:English
Published: BMC 2017-10-01
Series:BMC Bioinformatics
Subjects:
Human Phenotype Ontology
Hierarchical multi-label classification
Hierarchical ensemble methods
Gene-Abnormal phenotype association
Human Phenotype Ontology term prediction
Phenotype gene prioritization
Online Access:http://link.springer.com/article/10.1186/s12859-017-1854-y

Internet

http://link.springer.com/article/10.1186/s12859-017-1854-y

Similar Items