The Complex Function of Hsp70 in Metastatic Cancer

Elevated expression of the inducible heat shock protein 70 (Hsp70) is known to correlate with poor prognosis in many cancers. Hsp70 confers survival advantage as well as resistance to chemotherapeutic agents, and promotes tumor cell invasion. At the same time, tumor-derived extracellular Hsp70 has b...

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Bibliographic Details
Main Authors: Kata Juhasz, Anna-Maria Lipp, Benedikt Nimmervoll, Alois Sonnleitner, Jan Hesse, Thomas Haselgruebler, Zsolt Balogi
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Cancers
Subjects:
Online Access:http://www.mdpi.com/2072-6694/6/1/42