MyD88 Is Not Required for Muscle Injury-Induced Endochondral Heterotopic Ossification in a Mouse Model of Fibrodysplasia Ossificans Progressiva

MyD88 Is Not Required for Muscle Injury-Induced Endochondral Heterotopic Ossification in a Mouse Model of Fibrodysplasia Ossificans Progressiva

Excess inflammation and canonical BMP receptor (BMPR) signaling are coinciding hallmarks of the early stages of injury-induced endochondral heterotopic ossification (EHO), especially in the rare genetic disease fibrodysplasia ossificans progressiva (FOP). Multiple inflammatory signaling pathways can...

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Bibliographic Details
Main Authors: Huili Lyu, Cody M. Elkins, Jessica L. Pierce, C. Henrique Serezani, Daniel S. Perrien
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biomedicines
Subjects:
IL-1β
muscle injury and repair
chondrogenesis
osteogenesis
<i>Acvr1</i>
fibroadipoprogenitor
Online Access:https://www.mdpi.com/2227-9059/9/6/630

Internet

https://www.mdpi.com/2227-9059/9/6/630

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