Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis

Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis

Neutrophil extracellular traps (NETs) are known to promote metastasis in mouse models. Here the authors show plasma redox imbalance caused by albumin oxidation to induce inflammation-independent NETosis and lung metastasis, and albumin oxidation and reduced plasma free thiol to be associated with lu...

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Bibliographic Details
Main Authors: Minoru Inoue, Ryota Nakashima, Masahiro Enomoto, Yuhki Koike, Xiao Zhao, Kenneth Yip, Shao Hui Huang, John N. Waldron, Mitsuhiko Ikura, Fei-Fei Liu, Scott V. Bratman
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07550-x

Internet

https://doi.org/10.1038/s41467-018-07550-x

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