A Single Nucleotide Polymorphism in the Gene Promoter Affects Transcription and Influences Retinal Ganglion Cell Death

Pro-apoptotic Bax is essential for RGC (retinal ganglion cell) death. Gene dosage experiments in mice, yielding a single wild-type Bax allele, indicated that genetic background was able to influence the cell death phenotype. DBA/2J Bax +/− mice exhibited complete resistance to nerve damage after 2 w...

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Bibliographic Details
Main Authors: Sheila J Semaan, Yan Li, Robert W Nickells
Format: Article
Language:English
Published: SAGE Publishing 2010-03-01
Series:ASN Neuro
Online Access:https://doi.org/10.1042/AN20100003