Putative Origins of Cell-Free DNA in Humans: A Review of Active and Passive Nucleic Acid Release Mechanisms

Putative Origins of Cell-Free DNA in Humans: A Review of Active and Passive Nucleic Acid Release Mechanisms

Through various pathways of cell death, degradation, and regulated extrusion, partial or complete genomes of various origins (e.g., host cells, fetal cells, and infiltrating viruses and microbes) are continuously shed into human body fluids in the form of segmented cell-free DNA (cfDNA) molecules. W...

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Bibliographic Details
Main Authors: Stefan Grabuschnig, Abel Jacobus Bronkhorst, Stefan Holdenrieder, Ingund Rosales Rodriguez, Klaus Peter Schliep, Daniel Schwendenwein, Vida Ungerer, Christoph Wilhelm Sensen
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
cell-free DNA
circulating DNA
liquid biopsy
circulating tumor DNA
active release of cfDNA
passive release of cfDNA
Online Access:https://www.mdpi.com/1422-0067/21/21/8062

Internet

https://www.mdpi.com/1422-0067/21/21/8062

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