Use of Mendelian Randomization to Examine Causal Inference in Osteoporosis

Use of Mendelian Randomization to Examine Causal Inference in Osteoporosis

Epidemiological studies have identified many risk factors for osteoporosis, however it is unclear whether these observational associations reflect true causal effects, or the effects of latent confounding or reverse causality. Mendelian randomization (MR) enables causal relationships to be evaluated...

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Bibliographic Details
Main Authors: Jie Zheng, Monika Frysz, John P. Kemp, David M. Evans, George Davey Smith, Jonathan H. Tobias
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Endocrinology
Subjects:
bone mineral density (BMD)
fractures - bone
pleiotropy
sclerostin
GWAS - genome-wide association study
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00807/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2019.00807/full

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