Adeno-associated virus-mediated delivery of anti-miR-199a tough decoys attenuates cardiac hypertrophy by targeting PGC-1alpha

Adeno-associated virus-mediated delivery of anti-miR-199a tough decoys attenuates cardiac hypertrophy by targeting PGC-1alpha

MicroRNAs (miRNAs) are important regulators in the process of cardiac hypertrophy and heart failure. Previous studies have shown that miR-199a is upregulated in pressure-overload cardiac hypertrophy and that inhibition of miR-199a attenuates cardiac hypertrophy in vitro. However, the therapeutic rol...

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Bibliographic Details
Main Authors: Hualin Yan, Hong Wang, Xiaoxia Zhu, Jianbo Huang, Yifei Li, Kaiyu Zhou, Yimin Hua, Feng Yan, Da-Zhi Wang, Yan Luo
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
adeno-associated virus
microRNA-199a
cardiac hypertrophy
heart failure
PGC1-alpha
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120303632

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http://www.sciencedirect.com/science/article/pii/S2162253120303632

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