Phosphatidylcholine-specific phospholipase C inhibition down- regulates CXCR4 expression and interferes with proliferation, invasion and glycolysis in glioma cells.

Phosphatidylcholine-specific phospholipase C inhibition down- regulates CXCR4 expression and interferes with proliferation, invasion and glycolysis in glioma cells.

The chemokine receptor CXCR4 plays a crucial role in tumors, including glioblastoma multiforme (GBM), the most aggressive glioma. Phosphatidylcholine-specific phospholipase C (PC-PLC), a catabolic enzyme of PC metabolism, is involved in several aspects of cancer biology and its inhibition down-modul...

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Bibliographic Details
Main Authors: Laura Mercurio, Serena Cecchetti, Alessandro Ricci, Aurora Pacella, Giovanni Cigliana, Giuseppina Bozzuto, Franca Podo, Egidio Iorio, Giulia Carpinelli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5397108?pdf=render

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http://europepmc.org/articles/PMC5397108?pdf=render

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