PAX8 regulon in human ovarian cancer links lineage dependency with epigenetic vulnerability to HDAC inhibitors

PAX8 regulon in human ovarian cancer links lineage dependency with epigenetic vulnerability to HDAC inhibitors

PAX8 is a prototype lineage-survival oncogene in epithelial ovarian cancer. However, neither its underlying pro-tumorigenic mechanisms nor potential therapeutic implications have been adequately elucidated. Here, we identified an ovarian lineage-specific PAX8 regulon using modified cancer outlier pr...

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Bibliographic Details
Main Authors: Kaixuan Shi, Xia Yin, Mei-Chun Cai, Ying Yan, Chenqiang Jia, Pengfei Ma, Shengzhe Zhang, Zhenfeng Zhang, Zhenyu Gu, Meiying Zhang, Wen Di, Guanglei Zhuang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-05-01
Series:eLife
Subjects:
PAX8
regulon
ovarian cancer
lineage-survival oncogene
HDAC inhibitor
super-enhancer
Online Access:https://elifesciences.org/articles/44306

Internet

https://elifesciences.org/articles/44306

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