Knockout of c‐Cbl slows EGFR endocytic trafficking and enhances EGFR signaling despite incompletely blocking receptor ubiquitylation

Knockout of c‐Cbl slows EGFR endocytic trafficking and enhances EGFR signaling despite incompletely blocking receptor ubiquitylation

Abstract Epidermal growth factor receptor (EGFR) activity is necessary and sufficient for corneal epithelial homeostasis. However, the addition of exogenous Epidermal Growth Factor (EGF) does not reliably restore the corneal epithelium when wounded. This is likely due to high levels of endogenous EG...

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Bibliographic Details
Main Authors: Brandon L. M. Crotchett, Brian P. Ceresa
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:Pharmacology Research & Perspectives
Subjects:
c‐Cbl
corneal epithelium
EGFR
membrane trafficking
ubiquitylation
Online Access:https://doi.org/10.1002/prp2.756

Internet

https://doi.org/10.1002/prp2.756

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