Chondro-Protective Effects of Shikimic Acid on Osteoarthritis via Restoring Impaired Autophagy and Suppressing the MAPK/NF-κB Signaling Pathway

Chondro-Protective Effects of Shikimic Acid on Osteoarthritis via Restoring Impaired Autophagy and Suppressing the MAPK/NF-κB Signaling Pathway

Osteoarthritis (OA) is a major cause of cartilage pain and limited mobility in middle-aged and elderly individuals. The degeneration of cartilage induced by inflammation and cartilage anabolic and catabolic disorder plays a key role in OA. Shikimic acid (SA), a natural ingredient extracted from Illi...

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Bibliographic Details
Main Authors: Hongbo You, Rui Zhang, Lingying Wang, Qiyong Pan, Zekai Mao, Xiaojian Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
shikimic acid
osteoarthritis
autophagy
MMPs
MAPK
NF-κB
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.634822/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.634822/full

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