Live Cell Analysis and Mathematical Modeling Identify Determinants of Attenuation of Dengue Virus 2'-O-Methylation Mutant.

Live Cell Analysis and Mathematical Modeling Identify Determinants of Attenuation of Dengue Virus 2'-O-Methylation Mutant.

Dengue virus (DENV) is the most common mosquito-transmitted virus infecting ~390 million people worldwide. In spite of this high medical relevance, neither a vaccine nor antiviral therapy is currently available. DENV elicits a strong interferon (IFN) response in infected cells, but at the same time...

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Bibliographic Details
Main Authors: Bianca Schmid, Melanie Rinas, Alessia Ruggieri, Eliana Gisela Acosta, Marie Bartenschlager, Antje Reuter, Wolfgang Fischl, Nathalie Harder, Jan-Philip Bergeest, Michael Flossdorf, Karl Rohr, Thomas Höfer, Ralf Bartenschlager
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1005345

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https://doi.org/10.1371/journal.ppat.1005345

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