Differential kynurenine pathway metabolism in highly metastatic aggressive breast cancer subtypes: beyond IDO1-induced immunosuppression

Differential kynurenine pathway metabolism in highly metastatic aggressive breast cancer subtypes: beyond IDO1-induced immunosuppression

Abstract Background Immunotherapy has recently been proposed as a promising treatment to stop breast cancer (BrCa) progression and metastasis. However, there has been limited success in the treatment of BrCa with immune checkpoint inhibitors. This implies that BrCa tumors have other mechanisms to es...

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Bibliographic Details
Main Authors: Benjamin Heng, Ayse A. Bilgin, David B. Lovejoy, Vanessa X. Tan, Heloisa H. Milioli, Laurence Gluch, Sonia Bustamante, Tharani Sabaretnam, Pablo Moscato, Chai K. Lim, Gilles J. Guillemin
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Breast Cancer Research
Subjects:
Kynurenine pathway
Breast cancer
Biomarker
Immune evasion
Tryptophan
Online Access:http://link.springer.com/article/10.1186/s13058-020-01351-1

Internet

http://link.springer.com/article/10.1186/s13058-020-01351-1

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