4-chloro eugenol interacts synergistically with artesunate against drug resistant P. falciparum inducing oxidative stress

4-chloro eugenol interacts synergistically with artesunate against drug resistant P. falciparum inducing oxidative stress

4-chloro eugenol (4CE), a semisynthetic analog of phytomolecule eugenol exhibited potent antiplasmodial activity with IC50 in the range of 1.5–5 μM against sensitive as well as drug resistant strain of P. falciparum. This analog also showed synergy with a clinically used antimalarial drug artesunate...

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Bibliographic Details
Main Authors: Pooja Rani Mina, Saurabh Kumar, Karishma Agarwal, Ravi Kumar, Anirban Pal, Sudeep Tandon, Sanjeev Kumar Yadav, Sanjay Yadav, Mahendra P. Darokar
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
4-chloro eugenol
Reactive oxygen species
P. falciparum
Oxidative stress
Drug resistance
Synergy
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221000962

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http://www.sciencedirect.com/science/article/pii/S0753332221000962

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