Ex vivo AKT-inhibition facilitates generation of polyfunctional stem cell memory-like CD8+ T cells for adoptive immunotherapy

Ex vivo AKT-inhibition facilitates generation of polyfunctional stem cell memory-like CD8+ T cells for adoptive immunotherapy

Adoptive T cell therapy has shown clinical potential for patients with cancer, though effective treatment is dependent on longevity and potency of the exploited tumor-reactive T cells. Previously, we showed that ex vivo inhibition of AKT using the research compound Akt-inhibitor VIII retained differ...

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Bibliographic Details
Main Authors: Charlotte M. Mousset, Willemijn Hobo, Yun Ji, Hanny Fredrix, Valeria De Giorgi, Robert D. Allison, Michel G. D. Kester, J. H. Frederik Falkenburg, Nicolaas P. M. Schaap, Joop H. Jansen, Luca Gattinoni, Harry Dolstra, Anniek B. van der Waart
Format: Article
Language:English
Published: Taylor & Francis Group 2018-10-01
Series:OncoImmunology
Subjects:
akt
stem cell memory
cd8+ t cell
adoptive transfer
glycolysis
polyfunctionality
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1488565

Internet

http://dx.doi.org/10.1080/2162402X.2018.1488565

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