FLNC Gene Splice Mutations Cause Dilated Cardiomyopathy

FLNC Gene Splice Mutations Cause Dilated Cardiomyopathy

A genetic etiology has been identified in 30% to 40% of dilated cardiomyopathy (DCM) patients, yet only 50% of these cases are associated with a known causative gene variant. Thus, in order to understand the pathophysiology of DCM, it is necessary to identify and characterize additional genes. In th...

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Bibliographic Details
Main Authors: Rene L. Begay, BS, Charles A. Tharp, MD, August Martin, Sharon L. Graw, PhD, Gianfranco Sinagra, MD, Daniela Miani, MD, Mary E. Sweet, BA, Dobromir B. Slavov, PhD, Neil Stafford, MD, Molly J. Zeller, Rasha Alnefaie, Teisha J. Rowland, PhD, Francesca Brun, MD, Kenneth L. Jones, PhD, Katherine Gowan, Luisa Mestroni, MD, Deborah M. Garrity, PhD, Matthew R.G. Taylor, MD, PhD
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:JACC: Basic to Translational Science
Subjects:
cardiovascular genetics
dilated cardiomyopathy
filamin C
heart failure
zebrafish
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X16300328

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http://www.sciencedirect.com/science/article/pii/S2452302X16300328

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