Arginase Inhibition Reverses Monocrotaline-Induced Pulmonary Hypertension

Arginase Inhibition Reverses Monocrotaline-Induced Pulmonary Hypertension

Pulmonary hypertension (PH) is a heterogeneous disorder associated with a poor prognosis. Thus, the development of novel treatment strategies is of great interest. The enzyme arginase (Arg) is emerging as important player in PH development. The aim of the current study was to determine the expressio...

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Bibliographic Details
Main Authors: Christian Jung, Katja Grün, Stefan Betge, John Pernow, Malte Kelm, Johanna Muessig, Maryna Masyuk, Friedhelm Kuethe, Bernadin Ndongson-Dongmo, Reinhard Bauer, Alexander Lauten, P. Christian Schulze, Alexander Berndt, Marcus Franz
Format: Article
Language:English
Published: MDPI AG 2017-07-01
Series:International Journal of Molecular Sciences
Subjects:
pulmonary hypertension
monocrotaline rat model
arginase
isoforms
inhibition
Online Access:https://www.mdpi.com/1422-0067/18/8/1609

Internet

https://www.mdpi.com/1422-0067/18/8/1609

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