Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice

Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice

Abstract Fragile X syndrome is caused by the loss of fragile X mental retardation protein (FMRP). Kainate receptor (KAR) is a subfamily of ionotropic glutamate receptors (iGluR) that acts mainly as a neuromodulator of synaptic transmission and neuronal excitability. However, little is known about th...

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Bibliographic Details
Main Authors: Shuang Qiu, Yu Wu, Xinyou Lv, Xia Li, Min Zhuo, Kohei Koga
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Molecular Brain
Subjects:
FMRP
Fragile X syndrome
Insular cortex
Kainate receptor
Internalization
GluK1
Online Access:http://link.springer.com/article/10.1186/s13041-018-0396-1

Internet

http://link.springer.com/article/10.1186/s13041-018-0396-1

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