Altered insulin receptor signalling and β-cell cycle dynamics in type 2 diabetes mellitus.

Altered insulin receptor signalling and β-cell cycle dynamics in type 2 diabetes mellitus.

Insulin resistance, reduced β-cell mass, and hyperglucagonemia are consistent features in type 2 diabetes mellitus (T2DM). We used pancreas and islets from humans with T2DM to examine the regulation of insulin signaling and cell-cycle control of islet cells. We observed reduced β-cell mass and incre...

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Bibliographic Details
Main Authors: Franco Folli, Terumasa Okada, Carla Perego, Jenny Gunton, Chong Wee Liew, Masaru Akiyama, Anna D'Amico, Stefano La Rosa, Claudia Placidi, Roberto Lupi, Piero Marchetti, Giorgio Sesti, Marc Hellerstein, Lucia Perego, Rohit N Kulkarni
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3227614?pdf=render

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http://europepmc.org/articles/PMC3227614?pdf=render

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