PIK3CA mutations frequently coexist with RAS and BRAF mutations in patients with advanced cancers.

PIK3CA mutations frequently coexist with RAS and BRAF mutations in patients with advanced cancers.

Oncogenic mutations of PIK3CA, RAS (KRAS, NRAS), and BRAF have been identified in various malignancies, and activate the PI3K/AKT/mTOR and RAS/RAF/MEK pathways, respectively. Both pathways are critical drivers of tumorigenesis.Tumor tissues from 504 patients with diverse cancers referred to the Clin...

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Bibliographic Details
Main Authors: Filip Janku, J Jack Lee, Apostolia M Tsimberidou, David S Hong, Aung Naing, Gerald S Falchook, Siqing Fu, Rajyalakshmi Luthra, Ignacio Garrido-Laguna, Razelle Kurzrock
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3146490?pdf=render

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http://europepmc.org/articles/PMC3146490?pdf=render

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