MDC1 depletion promotes cisplatin induced cell death in cervical cancer cells

MDC1 depletion promotes cisplatin induced cell death in cervical cancer cells

Abstract Objective Cisplatin, the most common chemotherapeutic drug for the treatment of advanced stage cervical cancers has limitations in terms of drugs resistance observed in patients partly due to functional DNA damage repair (DDR) processes in the cell. Mediator of DNA damage checkpoint 1 (MDC1...

Full description

Bibliographic Details
Main Authors: Neeru Singh, Rashmi Bhakuni, Dimple Chhabria, Sivapriya Kirubakaran
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Research Notes
Subjects:
Cisplatin
Cervical cancer
DNA damage repair
Ataxia telangiectasia mutated
MDC1
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s13104-020-04996-5

Internet

http://link.springer.com/article/10.1186/s13104-020-04996-5

Similar Items