Single-Cell Transcriptomics Reveals Zone-Specific Alterations of Liver Sinusoidal Endothelial Cells in CirrhosisSummary

Single-Cell Transcriptomics Reveals Zone-Specific Alterations of Liver Sinusoidal Endothelial Cells in CirrhosisSummary

Background: Dysfunction of liver sinusoidal endothelial cells (LSECs) is permissive for the progression of liver fibrosis and cirrhosis and responsible for its clinical complications. Here, we have mapped the spatial distribution of heterogeneous liver ECs in normal vs cirrhotic mouse livers and ide...

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Bibliographic Details
Main Authors: Tingting Su, Yilin Yang, Sanchuan Lai, Jain Jeong, Yirang Jung, Matthew McConnell, Teruo Utsumi, Yasuko Iwakiri
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Liver Fibrosis
Portal Hypertension
scRNA-seq
Lymphatic Endothelial Cells
Endothelial Dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X2030206X

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http://www.sciencedirect.com/science/article/pii/S2352345X2030206X

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