Could AGE/RAGE-Related Oxidative Homeostasis Dysregulation Enhance Susceptibility to Pathogenesis of Cardio-Metabolic Complications in Childhood Obesity?

Could AGE/RAGE-Related Oxidative Homeostasis Dysregulation Enhance Susceptibility to Pathogenesis of Cardio-Metabolic Complications in Childhood Obesity?

Background: Advanced glycation end-products (AGEs) and their cell receptor (RAGE) are involved in the pathophysiology of cardio-metabolic diseases. Interaction of AGEs with RAGE results in increased generation of oxygen radicals and pro-inflammatory cytokines. Circulating soluble RAGE (sRAGE) intera...

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Bibliographic Details
Main Authors: Domenico Corica, Tommaso Aversa, Rosaria Maddalena Ruggeri, Mariateresa Cristani, Angela Alibrandi, Giorgia Pepe, Filippo De Luca, Malgorzata Wasniewska
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Endocrinology
Subjects:
oxidative stress
advanced glycation end-products
cardiometabolic risk
sRAGE
AGEs/sRAGE-ratio
advanced oxidation-protein products
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00426/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2019.00426/full

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