CPPs to the Test: Effects on Binding, Uptake and Biodistribution of a Tumor Targeting Nanobody

CPPs to the Test: Effects on Binding, Uptake and Biodistribution of a Tumor Targeting Nanobody

Nanobodies are well-established targeting ligands for molecular imaging and therapy. Their short circulation time enables early imaging and reduces systemic radiation exposure. However, shorter circulation time leads to lower tracer accumulation in the target tissue. Cell-penetrating peptides (CPPs)...

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Bibliographic Details
Main Authors: Estel Collado Camps, Sanne A. M. van Lith, Cathelijne Frielink, Jordi Lankhof, Ingrid Dijkgraaf, Martin Gotthardt, Roland Brock
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceuticals
Subjects:
cell-penetrating peptides
molecular imaging
nanobody
spheroids
tumor targeting
biodistribution
Online Access:https://www.mdpi.com/1424-8247/14/7/602

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https://www.mdpi.com/1424-8247/14/7/602

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