Acacetin and Chrysin, Two Polyphenolic Compounds, Alleviate Telomeric Position Effect in Human Cells

Acacetin and Chrysin, Two Polyphenolic Compounds, Alleviate Telomeric Position Effect in Human Cells

We took advantage of the ability of human telomeres to silence neighboring genes (telomere position effect or TPE) to design a high-throughput screening assay for drugs altering telomeres. We identified, for the first time, that two dietary flavones, acacetin and chrysin, are able to specifically al...

Full description

Bibliographic Details
Main Authors: Amina Boussouar, Caroline Barette, Robert Nadon, Adelaïde Saint-Léger, Natacha Broucqsault, Alexandre Ottaviani, Arva Firozhoussen, Yiming Lu, Laurence Lafanechère, Eric Gilson, Frédérique Magdinier, Jing Ye
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
DNA damage response
flavanoid
polyphenol
telomere
telomeric position effect
telomere-induced foci
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301743

Internet

http://www.sciencedirect.com/science/article/pii/S2162253116301743

Similar Items