Chronic exposure to tumor necrosis factor alpha induces retinal pigment epithelium cell dedifferentiation

Chronic exposure to tumor necrosis factor alpha induces retinal pigment epithelium cell dedifferentiation

Abstract Background The retinal pigment epithelium (RPE) is a monolayer of pigmented cells with important barrier and immuno-suppressive functions in the eye. We have previously shown that acute stimulation of RPE cells by tumor necrosis factor alpha (TNFα) downregulates the expression of OTX2 (Orth...

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Bibliographic Details
Main Authors: Sara Touhami, Fanny Beguier, Sébastien Augustin, Hugo Charles-Messance, Lucile Vignaud, Emeline F. Nandrot, Sacha Reichman, Valérie Forster, Thibaud Mathis, José-Alain Sahel, Bahram Bodaghi, Xavier Guillonneau, Florian Sennlaub
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Neuroinflammation
Subjects:
Retinal pigment epithelium
Tumor necrosis factor alpha
Transforming growth factor beta
Age-related macular degeneration
Neuroinflammation
Neurodegenerative disease
Online Access:http://link.springer.com/article/10.1186/s12974-018-1106-8

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http://link.springer.com/article/10.1186/s12974-018-1106-8

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