Network-level allosteric effects are elucidated by detailing how ligand-binding events modulate utilization of catalytic potentials.
Allosteric regulation has traditionally been described by mathematically-complex allosteric rate laws in the form of ratios of polynomials derived from the application of simplifying kinetic assumptions. Alternatively, an approach that explicitly describes all known ligand-binding events requires no...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-08-01
|
| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC6097697?pdf=render |