LGR5 is expressed by Ewing sarcoma and potentiates Wnt/β-catenin signaling

LGR5 is expressed by Ewing sarcoma and potentiates Wnt/β-catenin signaling

Ewing sarcoma (ES) is an aggressive bone and soft tissue tumor of putative stem cell origin that predominantly occurs in children and young adults. Although most patients with localized ES can be cured with intensive therapy, the clinical course is variable and up to one third of patients relapse f...

Full description

Bibliographic Details
Main Authors: Christopher A Scannell, Elisabeth A Pedersen, Jack T Mosher, Melanie Anne Krook, Lauren A Nicholls, Breelyn A Wilky, David M. Loeb, Elizabeth R Lawlor
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-04-01
Series:Frontiers in Oncology
Subjects:
beta Catenin
stem cell
Wnt
Ewing sarcoma
LGR5
R-spondin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00081/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00081/full

Similar Items