Tyrosine Mutation in AAV9 Capsid Improves Gene Transfer to the Mouse Lung

Tyrosine Mutation in AAV9 Capsid Improves Gene Transfer to the Mouse Lung

Background/Aims: Adeno-associated virus (AAV) vectors are being increasingly used as the vector of choice for in vivo gene delivery and gene therapy for many pulmonary diseases. Recently, it was shown that phosphorylation of surface-exposed tyrosine residues from AAV capsid targets the viral particl...

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Bibliographic Details
Main Authors: Sabrina V. Martini, Adriana L. Silva, Debora Ferreira, Rafael Rabelo, Felipe M. Ornellas, Karina Gomes, Patricia R.M. Rocco, Hilda Petrs-Silva, Marcelo M. Morales
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Adeno-associated virus serotype 9
Tyrosine mutant
Gene therapy
Lung mechanics
Online Access:http://www.karger.com/Article/FullText/445646

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http://www.karger.com/Article/FullText/445646

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