Divergent Effects of the N-Methyl-D-Aspartate Receptor Antagonist Kynurenic Acid and the Synthetic Analog SZR-72 on Microcirculatory and Mitochondrial Dysfunction in Experimental Sepsis

Divergent Effects of the N-Methyl-D-Aspartate Receptor Antagonist Kynurenic Acid and the Synthetic Analog SZR-72 on Microcirculatory and Mitochondrial Dysfunction in Experimental Sepsis

Introduction: Sepsis is a dysregulated host response to infection with macro- and microhemodynamic deterioration. Kynurenic acid (KYNA) is a metabolite of the kynurenine pathway of tryptophan catabolism with pleiotropic cell-protective effects under pro-inflammatory conditions. Our aim was to invest...

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Bibliographic Details
Main Authors: László Juhász, Attila Rutai, Roland Fejes, Szabolcs P. Tallósy, Marietta Z. Poles, Andrea Szabó, István Szatmári, Ferenc Fülöp, László Vécsei, Mihály Boros, József Kaszaki
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Medicine
Subjects:
polymicrobial sepsis
kynurenic acid
N-methyl-D-aspartate receptor antagonist
microcirculation
mitochondrial respiration
organ dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2020.566582/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2020.566582/full

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